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Description
GM-CSFR α His Tag Protein, MouseProduct Specification Species Mouse Synonyms GMR, CD116, CSF2R, SMDP4 Accession Q00941 Amino Acid Sequence Leu30 Pro327, with C 8*His Expression System HEK293 Molecular Weight 44 60kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability
Product Specification
| Species | Mouse |
| Synonyms | GMR, CD116, CSF2R, SMDP4 |
| Accession | Q00941 |
| Amino Acid Sequence | Leu30-Pro327, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 44-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Prevost J M. et al. (2002) Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Inflammatory Stimuli Up-Regulate Secretion of the Soluble GM-CSF Receptor in Human Monocytes: Evidence for Ectodomain Shedding of the Cell Surface GM-CSF Receptor α Subunit. J Immunol. 169(10): 5679-5688. 2、Cao Y. et al. (2007) Angiogenesis modulates adipogenesis and obesity. J Clin Invest. 117(9): 2362-2368. 3、Fleetwood A J. et al. (2005) Functions of Granulocyte-Macrophage Colony-Stimulating Factor. Crit Rev Immunol. 25(5): 405-428. |
Background
GM-CSF receptor alpha is a member of the cytokine family of receptors. GM-CSF receptor alpha is found in the pseudoautosomal region of the X and Y chromosomes. GM-CSF receptor alpha has different isoform, with some of the isoforms being membrane-bound and others being soluble. Soluble GM-CSF receptor alpha subunit is a soluble isoform of the GMR alpha that is believed to arise exclusively through alternative splicing of the GMR alpha gene product. The sGMR alpha mRNA is expressed in a variety of tissues, but it is not clear which cells are capable of secreting the protein. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in GM-CSF receptor alpha, which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages. While no pharmacologic therapy currently exists for hPAP, it was recently demonstrated that endotracheal instillation of wild-type or gene-corrected mononuclear phagocytes results in a significant and durable therapeutic efficacy in a validated murine model of hPAP.
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4.1 ★★★★★
Based on 1430 reviews
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Product Reviews
★★★★★ 3
Good quality - not very useful
Good quality utility pouch, downside is no recent phones will fit in this pouch as shown and the strap on the back is useless. Would've returned it but liked that it is waterproof and can hold thin items. Not the best value for the money if you wanted to protect a phone. Zipper is very sturdy. Too thin to be functional.
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Reviewed in the United States on September 15, 2025
★★★★★ 5
The Casio AEQ110 BW is worth it meets all the basics
Color: Black, Style: AEQ110W-1AV
Its indeed a lovely casio watch.....meets all standards only downfall it has no illumination
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Reviewed in the United States on April 29, 2026
★★★★★ 5
Very nice for the price!!!
Color: Black, Style: AEQ110W-1AV
Very, very Nice inexpensive watch!! Kinda tough to set it up but when done its well worth it. The icons glow so no light. The watch is a good smaller on my wrist than I expected but its functional not style Ineeded.
Still a verry good watch, no questions asked!!
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Reviewed in the United States on July 18, 2025
★★★★★ 5
Well built under $50 watch.
I got this Casio as my first Casio as I've worn watches since I was a teenager, using non brand sport watches and eventually graduating to fancy Japanese watches. Now I found myself not wanting to use those to put on wear on them because they are automatic and require some maintenance, so I figured it was time I got my first Casio. I was skeptical at first because I knew I wanted a Casio but the designs were all, dare I say generic (Or so I thought) so I ultimately wanted a G shock but, for the price and intended purpose I found this watch that just checked the boxes in design and "10-Year" battery. When I got it in the mail I was stocked, I hadn't felt a resin watch in years and set up was straight forward. Now after weeks of use I've found that through a bunch of me smacking it and hand washes, it still looks new, fortifying my satisfaction in buying this. Can recommend.
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Reviewed in the United States on February 17, 2025
★★★★★ 4
Excelente reloj
Color: Black/Black, Style: AEQ110W-1BV
Excelente reloj
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Reviewed in the United States on May 3, 2026